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Ryuji Ueno Selected Research

Lubiprostone

2/2015Lubiprostone increases spontaneous bowel movement frequency and quality of life in patients with chronic idiopathic constipation.
11/2014A randomized study of lubiprostone for opioid-induced constipation in patients with chronic noncancer pain.
3/2014Lubiprostone for the treatment of functional constipation in children.
9/2011Long-term safety and effectiveness of lubiprostone, a chloride channel (ClC-2) activator, in patients with chronic idiopathic constipation.
2/2011Lubiprostone reverses the inhibitory action of morphine on mucosal secretion in human small intestine.
4/2010Efficacy and safety of lubiprostone in patients with chronic constipation.
1/2008Multicenter, 4-week, double-blind, randomized, placebo-controlled trial of lubiprostone, a locally-acting type-2 chloride channel activator, in patients with chronic constipation.
2/2007Recovery of mucosal barrier function in ischemic porcine ileum and colon is stimulated by a novel agonist of the ClC-2 chloride channel, lubiprostone.
5/2006Effect of a selective chloride channel activator, lubiprostone, on gastrointestinal transit, gastric sensory, and motor functions in healthy volunteers.
11/2004SPI-0211 activates T84 cell chloride transport and recombinant human ClC-2 chloride currents.

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Ryuji Ueno Research Topics

Disease

8Constipation
02/2015 - 05/2006
1Dengue (Dengue Fever)
12/2017
1Infections
12/2017
1Falciparum Malaria (Plasmodium falciparum Malaria)
07/2017
1Irritable Bowel Syndrome (Syndrome, Irritable Bowel)
02/2015
1Pain (Aches)
11/2014
1Diarrhea
11/2014
1Opioid-Induced Constipation
11/2014
1Nausea
11/2014
1Ischemia
02/2007
1Dry Eye Syndromes (Dry Eye Syndrome)
02/2007
1Cystic Fibrosis (Mucoviscidosis)
11/2004

Drug/Important Bio-Agent (IBA)

10LubiprostoneFDA Link
02/2015 - 11/2004
3Chloride Channels (Chloride Channel)IBA
09/2011 - 05/2006
2VaccinesIBA
12/2017 - 07/2017
1AntigensIBA
07/2017
1Proteins (Proteins, Gene)FDA Link
07/2017
1Morphine (MS Contin)FDA LinkGeneric
02/2011
1Opioid Analgesics (Opioids)IBA
02/2011
1Therapeutic UsesIBA
02/2007
1AlbuminsIBA
02/2007
1Mannitol (Osmitrol)FDA LinkGeneric
02/2007
1Serum AlbuminIBA
02/2007